PATHOS Project (2019-2024).It is the purpose of PATHOS to pursue our potentially ground-breaking multidisciplinary effort in biomedical diagnostics. Starting from novel fundamental approaches to dynamical control, we seek to create new paradigms concerning control or guidance of spin evolutions in complex spin networks, so as to gear them to hitherto unforeseen MR applications in chemistry, biology and medicine. In a nutshell, PATHOS aims to further the very fruitful synergy pioneered by our partners towards developing new task-oriented comprehensive sensing strategies and exploring the new frontiers they entail for NMR, optical and MRI based analysis.
|
PATHOS Deliverables
|
Deliverable Number |
Deliverable
Title |
WP |
Lead
beneficiary |
Type |
Dissemination
Level |
Due
Date (in
months) |
|
D4.1 |
WEB |
4 |
UNIFI |
Web,
etc. |
Public |
2 |
|
D4.2 |
Data Management Plan |
4 |
Weizmann |
ORDP |
Public |
6 |
|
D4.9 |
Dissemination &
Exploitation Plan 1 |
4 |
Weizmann |
Report |
Confidential |
6 |
|
D2.5 |
Non-Markovian probes |
2 |
UNIFI |
Report |
Public |
11 |
|
D1.5 |
AZE heteronuclear |
1 |
Weizmann |
Report |
Confidential |
12 |
|
D1.6 |
AZD homonuclear |
1 |
Weizmann |
Report |
Public |
12 |
|
D3.5 |
NV imager |
3 |
HUJI |
Report |
Public |
12 |
|
D3.6 |
Optical CS imaging |
3 |
HUJI |
Report |
Public |
12 |
Deliverable (public) reports
D4.1 WEB
D4.2 Data Management Plan
D2.5 Non-Markovian Probes
D1.6 AZD homonuclear
D3.5 NV imager
D3.6 Optical CS imaging
D4.1 WEB
D4.2 Data Management Plan
D2.5 Non-Markovian Probes
D1.6 AZD homonuclear
D3.5 NV imager
D3.6 Optical CS imaging
Work performed from the beginning of the project
During the first year of PATHOS project, we have advanced as planned and contributed to all our WPs towards the expected long-term objectives.
From the theory side, we have introduced conceptually novel approaches to the enhancement of heteronuclear spin-polarization transfer by means of repeated measurements, phase flips or spin-orientation flips for one of the spin species (alias the probe). Secondly, we have proposed new optics experiments for Zeno-based noise spectroscopy and studied several aspects of non-Markovian probes where the noise is correlated in time. Moreover, we have been working on the general formulation of the theory and practice of filtering environmental noise. Finally, we are also exploring a new path (not expected in PATHOS) where more recent deep learning techniques can improve the sensing properties of our classical and quantum probes.
From the experimental side, we have constructed a widefield NV-based magnetic microscope, to form the basis for the experimental demonstrations in this project. We have initiated studies of enhanced magnetic sensing capabilities through compressed sensing techniques. We have developed novel schemes for controlling dense, interacting spin ensembles, through robust pulses relying on rapid adiabatic passage, as well as generalized sequences based on the icosahedral symmetry group. Besides, we have studied spin bath coupling through advanced noise spectroscopy schemes, achieving both efficient bath characterization using uneven echo sequences, as well as detailed spectroscopy with modulated, continuous control (the gDYSCO scheme). In addition, we have improved the sensitivity of spectroscopy methods based on homonuclear mixing and recoupling in magnetic resonance experiments, and, as new and unexpected research direction, we have successfully applied these ideas into Coronavirus-related problems. Moreover, we have shown a spectral super-resolution reconstruction by using random lasers and also started preparing the setup for an optical experimental study of Zeno dynamics and related-sensing applications. Finally, we have upgraded our setups in several ways resulting in an increase of magnetic field sensitivity of ODMR-based magnetometry protocols ultimately for applications of sensing in biological systems.
These achievements have been disseminated in the scientific literature and via international conferences and non-specialist meetings, and form the basis for current efforts of studying quantum spatially and temporally correlated bath dynamics, further testing our theoretical results with our experimental platforms, proposing novel sensing protocols by further exploiting optimal control and compressed sensing, keeping enhancing the sensitivity of our biomolecular NMR, MRI and ODMR schemes, which follows the future plans of the project.
From the theory side, we have introduced conceptually novel approaches to the enhancement of heteronuclear spin-polarization transfer by means of repeated measurements, phase flips or spin-orientation flips for one of the spin species (alias the probe). Secondly, we have proposed new optics experiments for Zeno-based noise spectroscopy and studied several aspects of non-Markovian probes where the noise is correlated in time. Moreover, we have been working on the general formulation of the theory and practice of filtering environmental noise. Finally, we are also exploring a new path (not expected in PATHOS) where more recent deep learning techniques can improve the sensing properties of our classical and quantum probes.
From the experimental side, we have constructed a widefield NV-based magnetic microscope, to form the basis for the experimental demonstrations in this project. We have initiated studies of enhanced magnetic sensing capabilities through compressed sensing techniques. We have developed novel schemes for controlling dense, interacting spin ensembles, through robust pulses relying on rapid adiabatic passage, as well as generalized sequences based on the icosahedral symmetry group. Besides, we have studied spin bath coupling through advanced noise spectroscopy schemes, achieving both efficient bath characterization using uneven echo sequences, as well as detailed spectroscopy with modulated, continuous control (the gDYSCO scheme). In addition, we have improved the sensitivity of spectroscopy methods based on homonuclear mixing and recoupling in magnetic resonance experiments, and, as new and unexpected research direction, we have successfully applied these ideas into Coronavirus-related problems. Moreover, we have shown a spectral super-resolution reconstruction by using random lasers and also started preparing the setup for an optical experimental study of Zeno dynamics and related-sensing applications. Finally, we have upgraded our setups in several ways resulting in an increase of magnetic field sensitivity of ODMR-based magnetometry protocols ultimately for applications of sensing in biological systems.
These achievements have been disseminated in the scientific literature and via international conferences and non-specialist meetings, and form the basis for current efforts of studying quantum spatially and temporally correlated bath dynamics, further testing our theoretical results with our experimental platforms, proposing novel sensing protocols by further exploiting optimal control and compressed sensing, keeping enhancing the sensitivity of our biomolecular NMR, MRI and ODMR schemes, which follows the future plans of the project.
